Visitors to Hobart's city centre this weekend will be the first to catch a glimpse of the city's newest structural addition - an air-bridge over Argyle Street linking the Royal Hobart Hospital and new outpatient Clinics in the Wellington Centre.

The Minister for Health, Michelle O'Byrne, today announced that the installation of the air-bridge on Sunday marked another exciting milestone within Royal Hobart Hospital's redevelopment journey.

"The air-bridge will provide safe and convenient access for patients and clinicians to a number of outpatient clinics and services that will be relocated towards the end of the year," Ms O'Byrne said.

"To be known as the Wellington Clinics, the close proximity to the RHH will make it easier for not only clinicians working across both sites, but also for patients referred to and from other services on the hospital's main campus.

"After working closely with the Hobart City Council and the Tasmanian Heritage Council, we have created a structural feature that is not only functional but adds greatly to the streetscape whilst respecting the heritage and urban value of the local area.

"The new clinics will also mean a reduction in pedestrian traffic on the main RHH campus, particularly during the redevelopment works which will continue until 2016.

"The RHH redevelopment is the State's largest ever health infrastructure investment with total State and Federal funding of more than $580 million enabling us to deliver a contemporary health care facility equipped to respond to the health needs of Tasmanians now and into the future," she said.

The air-bridge, which was pre-fabricated in Launceston before being shipped to Hobart's Macquarie Wharf for fitting of external cladding and glazing, was transported up Argyle Street using over-sized trucks and elevated into place with large cranes.

The air-bridge will open to the public along with the Wellington Clinic services later this year.

Outpatient clinic services to be relocated include: Ear Nose Throat; Eye; Orthopaedics; Audiology; Medical and Surgical; Hand Physiotherapy; Cardio Respiratory; Special Dental; Plaster and Oral Maxillo-Facial.

A significant community engagement campaign will be undertaken to advise patients of the new location and parking availability.