Acting Premier Bryan Green has expressed his deepest sympathy on behalf of the State Government to people affected by the fatal bus crash at Elizabeth Town this afternoon.

Mr Green said he was extremely saddened at the news of the crash and said it would undoubtedly take a toll on North-West communities.

"This is a tragic accident which will cause significant grief to families and loved ones of all those involved.

"I express particular sympathy to the relatives of the two people who died in the crash.

"I'm sure all of Tasmania shares my hopes that the other people injured in the crash recover from their injuries and the undoubtable psychological toll that such a terrible incident can cause.

"I realise that at times like this words can mean very little, but I wish everyone coping with the aftermath of this crash every strength for the time ahead," Mr Green said.